A Satellite Event of the FENS Forum 2018, Berlin

From Scanner to Bedside

What do connectome and gene expression say about brain diseases?

Chair:

Prof. Dr. Marcus Kaiser, Connectomics Lab, University of Newcastle
Dr. Markus Butz-Ostendorf, Brain Science Domain, Biomax Informatics AG

Abstract

The connectome is regarded as the key to brain function in health and disease. Functional magnetic resonance imaging and diffusion imaging, among other techniques, enable us to measure functional and structural brain connectivity in the living human brain. Neural receptors mediate between structural and functional connectivity: They turn synaptic neurotransmitter transmission delivered by structural connections impinging on linked areas into neural activation again and ultimately determine the sign and strength of the structural connection. Moreover, synaptic transmission and neurotransmitter synthesis crucially depend on molecular constraints such as gene expression.

Positron emission tomography can visualize not only brain activation states but also specific transmitter release and the density of individual receptors. Pathological changes in connectivity and in the individual receptor fingerprint of areas, among other molecular markers, are very often specific indicators of brain diseases. Hence, neuroimaging becomes of increasing relevance for diagnosing brain diseases and informing treatment.

In this satellite symposium, research with a high potential for applications in neurology and psychiatry is presented. We want to bring together scientists with clinicians from all disciplines dealing with brain diseases and to provide a forum for discussion and exchange what steps are needed to bring novel techniques into clinical applications.

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Program

8:30 – 9:15 am Registration
9:15 am DR. KLAUS HEUMANN
(CEO Biomax Informatics AG, Planegg, Germany)
 
Welcome
9:30 am PROF. DR. ANDREAS MEYER-LINDENBERG
(Zentralinstitut für seelische Gesundheit, Mannheim, Germany)
 
Keynote lecture:
Neuroimaging in the diagnosis of mental disorders
10:30 am Break
11:00 am DR. WILLEM DE HAAN
(VUmc, Amsterdam, The Netherlands)
 
MEG of the Alzheimer’s disease brain
11:40 am PROF. DR. OLIVER HOWES
(Imperial College, London, UK)
 
PET/MRI imaging to test etiological hypotheses of psychotic disorders
12:20 pm DR. MARKUS BUTZ-OSTENDORF
(Biomax Informatics AG, Planegg, Germany)
 
Semantic integration of connectome and gene expression data
1:00 pm Lunch
2:00 pm PROF. DR. ED BULLMORE
(Cambridge University, Cambridge, UK)
 
Keynote lecture:
Connectome analysis of brain network disorders
3:00 pm DR. ROMAN BAUER
(University of Newcastle, Newcastle, UK)
 
Computational modelling of normal and pathological neural development
3:40 pm PROF. PETRA RITTER
(Charité, Berlin, Germany)
 
The Virtual Brain
4:20 pm Break
4:40 pm PROF. DR. DR. ELISABETH BINDER
(Max-Planck Institute for Psychiatry, Munich, Germany)
 
Keynote lecture:
Genetics and epigenetics of stress-related psychiatric disorders

Venue
Harnack House
The Conference Venue of the Max Planck Society
Ihnestraße 16-20
14195 Berlin
Germany

Registration
Registration via the symposium’s website is required. No registration fees apply.
For more information contact: .

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